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Chemistry. (+/-)O-Desmethyltramadol, or 3- (2- ( (dimethylamino)methyl)-1-hydroxycyclohexyl)phenol, is an atypical synthetic opioid. O-Desmethyltramadol is loosely analogous to codeine, but is not a morphinan opiate. Instead, it contains two rings including a cyclohexane ring that is bonded to a phenyl ring at R 1.Methadone (sold under trade names such as Dolophine and Methadose) is a synthetic opioid analgesic used for the treatment of moderate to severe pain and for the treatment of opioid addiction. It is commonly used to treat and manage the symptoms of opioid addiction. The subjective effects are similar to those of other synthetic opioids such as fentanyl, however, most users note a significantly ...DXM于1953年首次被报告，1958年在美国被批准用作止咳药，后以Romilar为名作为非处方药上市。早在1975年，人们业已认识到DXM被广泛滥用，为此，Romilar自愿退出市场。几年后，一些公司开始推出各种精制的DXM药品，如以加入气味难闻或苦涩的成分来防止被滥用。the trick is in the timing. drop blot about an hour-hour and a half after you dose with the dex. the drugs do not counteract each other, trust me on that one. you could also have an issue with the acid being sub-par, or the dxm impure for that matter. in france we have pure DXM pills so extraction is not an issue.This page lists substances that can be used for psychonautics. See list of pharmaceuticals for medical use of substances (e.g. antidotes, nootropics, and antipsychotics). Also, please don't add entries without existing articles here, add (or merge the current ones) to list/substances-new instead. Psychedelics Classical psychedelicsDextromethorphan (also known as robo, dex, DM, and DXM) is a dissociative substance of the morphinan class. It is the primary active ingredient in many common over-the-counter (OTC) cold and cough medicines. When exceeding approved doses, DXM produces dissociative effects similar to those of ketamine and phencyclidine (PCP). It acts as a noncompetitive NMDA receptor antagonist [1]. Experience reports - DXM. Age: 18 Height: 5'8" Weight: 54 kg / 120 lbs Dosage: 354 mg DXM. Report. At midnight, I grabbed an empty water bottle and quietly left my house. When I got to my car outside, I opened the trunk and tore the plastic thing off of the cap to a single bottle of cough syrup. Dextromethorphan (DXM) is a common component of combination cold medications that has become a popular drug of abuse for young adults. Abusers of DXM have developed a simple acid-base extraction technique to "free-base," or extract, the DXM from the unwanted guaifenesin, coloring agents, sweeteners, and alcohol that are typically included in …Oxymorphone (also known by the brand name Opana) is a semi-synthetic opioid analgesic used in the management of moderate to severe pain, and is similar in structure to other opioids such as morphine and heroin. Oxymorphone was first developed in Germany in 1914[2]and introduced to the American market in 1959.[3] Unlike many other opioids, oxymorphone is almost devoid of antitussive properties ... It feels great! I'm feeling very distinctly dissociated at a second plateau while talking to my girlfriend. I feel incredibly enthusiastic about DXM and subjective effect documentation in general. 10:54 pm - I decide to lay back on my recliner armchair and snuggle my girlfriend. This is where the trip begins to become surprisingly psychedelic.Dissociatives (also referred to as dissociative anesthetics) are a class of hallucinogen. Members of this class are characterized by distorted sensory perceptions and feelings of disconnection or detachment from the environment and self. The phenomenology is often described in terms of reducing or blocking signals to the conscious mind from other parts …DXM. Acid-base DXM extraction; Ibogaine. Iboga TA extraction; Kratom. Multisolvent heatless extraction of Kratom; LSA. Tincture of LSA extract; Simple Low Nausea LSA …Experience index. This section of PsychonautWiki is dedicated to providing a catalog of written personal experiences involving hallucinogens or other psychoactive substances. It is organized so as to link each report with its relevant subjective effects (for future projects utilizing large-scale data analysis).Tyrosine (also known as L-Tyrosine and 4-hydroxyphenylalanine) is a non-essential amino acid that serves a precursor to dopamine, adrenaline and norepinephrine in the human body. As a supplement, it is reported to act as a mild stimulant. It is also one of the 22 amino acids that are used by cells to synthesize proteins and is abundant in many high-protein foods, such as chicken, turkey, fish ...DXM and DPH both increase heart rate, possibly to very strenuous levels that can turn dangerous. Very high doses should be avoided because of this. Duration. Depending on dose, peak effects last between 6 - 12 hours and the total duration approximately 12- 20 hours. Please note these estimates are purely from my own experience.

Morphinan is comprised of a 1-benzylisoquinoline backbone with two additional ring closures. It features three benzene rings, where two are partially unsaturated, as well as a piperidine ring. It can have various substitutions at R 3 and R 6, and it is commonly substituted at R N with a methyl group and at R 4 and R 5 with an ether linkage to ...Dextromethorphan (DXM) is a cough suppressant in over-the-counter cold and cough medicines. It affects NMDA , glutamate-1, and sigma-1 receptors in the brain, all of which have been implicated in the pathophysiology of depression. Administration. Type: Anti-tussive. Dosage Forms: Routes of Administration: Common Trade Names: Active ingredient in many combination OTC cough/cold medications.Ketamine (also known as Ket, K, Special K, vitamin K,[5] Kitty, and others) is a classical dissociative substance of the arylcyclohexylamine class. It is perhaps the best-known and archetypal member of the dissociatives, a diverse group which includes PCP, methoxetamine, DXM, and nitrous oxide. The mechanism of action is not fully known, although blocking of the NMDA glutamate receptor is ... The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an NMDA receptor antagonist as well as essentially inactive as a serotonin reuptake inhibitor. DXO is an active chemical and contributes to the subjective effects experienced when active doses of DXM are consumed.

Hydrocodone (commonly sold as Vicodin or Norco when combined with paracetamol) is a semi-synthetic opioid morphinan synthesized or chemically derived from codeine, one of the opioid alkaloids found in the opium poppy. It is a narcotic analgesic used orally as a cough suppressant, but also commonly taken orally for relief of moderate to severe pain.[2] …Psychonautics (from the Ancient Greek ψυχή psychē 'soul, spirit, mind' and ναύτης naútēs 'sailor, navigator') [1] refers both to a methodology for describing and explaining the subjective effects of altered states of consciousness, including those induced by meditation or mind-altering substances, and to a research cabal in which ...Experience reports - DXM. Date: 04/16/2020 Age: 16 Sex: Female Height: 6'1" Weight: 147lbs/66.6kg Misc: Noisy setting; Enzyme deficiency; First experience Report. I'm a person who is very interested in the use of substances for purposes outside of simply having fun or getting high for the sake of getting high and have been wanting to try a psychedelic for quite a while, however the most I've ...…

Reader Q&A - also see RECOMMENDED ARTICLES & FAQs. Substance: DXM 15mg Gelcaps, 25mg DPH to help with nausea. (20 DXM pi. Possible cause: 1 Day one.. 1.1 Initial dose: Twenty-two Robotabs (660mg DXM freebase), six or seven hi.